猎奇重口

Trees with fall foliage surrounding Main Hall on the 猎奇重口 campus

Center for Environmental Health Sciences

Lung: Gases and Particles, Asthma, Fibrosis, Cancer

Andrij Holian, Ph.D. (Nanotechnology, Lung Fibrosis, Particles, Methamphetamine, Epigenetics and Diet)

  • Characterize mechanisms of particle and nanoparticle uptake by macrophages and the potential role of scavenger receptors in regulating lung inflammation
  • Defining the mechanisms of particle-induced lysosomal disruption leading to NLRP3 inflammasome activation and characteristics of nanoparticles leading to lung pathology
  • Characterize the role of the innate immune response by macrophages contributing to acute and chronic inflammation

Zeina Jaffar, Ph.D. (Lung: Gases & Particles; Systemic Immune)

  • The use of cannabinoid agonists as novel therapeutic agents in suppressing allergic airway inflammation in a mouse model of asthma
  • The role of innate immunity in ozone-induced lung inflammation and asthma exacerbations
  • The role of iNKT cells in the development of allergic lung inflammation

Chris Migliaccio, Ph.D. (Lung: gases & Particles; Epigenetics; Systemic Immune)

  • The effects of inhaled particles on pulmonary immunity and the regulation of inflammatory responses
  • The effects of diet and environmental exposures on immune regulation and pulmonary functions via epigenetic changes
  • Environmental changes to macrophage populations and the subsequent immune dysregulation of inflammatory responses (Lung: Gases & Particles; Systemic Immune)
  • The use of PGI2 and its analogs to regulate allergic airway inflammation in a mouse model of asthma
  • The role of IL-17 producing innate T cells and pentraxin-2 in resolving allergic lung inflammation
  • The use of S-nitroglutathione reductase (GSNOR) inhibitors to limit allergic lung inflammation

Kevan Roberts, Ph.D. (Lung: Gases & Particles; Systemic Immune)

  • The use of PGI2 and its analogs to regulate allergic airway inflammation in a mouse model of asthma
  • The role of IL-17 producing innate T cells and pentraxin-2 in resolving allergic lung inflammation
  • The use of S-nitroglutathione reductase (GSNOR) inhibitors to limit allergic lung inflammation