Epigentics: Environment, Diet, Susceptibility
Yoon Hee Cho, Ph.D. (Epigenetics, Toxicology, and Epidemiology)
- Defining the relationship between environmental exposure and epigenetic patterns to identify biomarkers and underlying mechanisms
- Investigating the roles of epigenetic modifications on inflammation and lung dysfunction after exposure to particles
- Evaluating the impact of early-life exposure to endocrine-disrupting chemicals on epigenetic regulation, which affects the susceptibility to reproductive disorders
Andrij Holian, Ph.D. (Nanotechnology, Lung Fibrosis, Particles, Methamphetamine, Epigenetics and Diet)
- Characterize mechanisms of particle and nanoparticle uptake by macrophages and the potential role of scavenger receptors in regulating lung inflammation
- Defining the mechanisms of particle-induced lysosomal disruption leading to NLRP3 inflammasome activation and characteristics of nanoparticles leading to lung pathology
- Characterize the role of the innate immune response by macrophages contributing to acute and chronic inflammation
Chris Migliaccio, Ph.D. (Lung: gases & Particles; Epigenetics; Systemic Immune)
- The effects of inhaled particles on pulmonary immunity and the regulation of inflammatory responses
- The effects of diet and environmental exposures on immune regulation and pulmonary functions via epigenetic changes
- Environmental changes to macrophage populations and the subsequent immune dysregulation of inflammatory responses